“Sleep is the form of payback towards the fatigue & we certainly have to repay this towards the proper functioning of our body and the brain. “
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The impact of chronic sleep disruption and reduced sleep on the promotion and interaction of physiological stress via the hypothalamic-pituitary-adrenal (HPA) and sympatho-adreno-medullary (SAM) axes and psychosocial stress.
Whereby sleep loss and fatigue result in an imbalance between the demands placed upon an individual and an inability of the individual to manage these demands. Ultimately, the combined and interlocking effects of physiological and psychosocial stress lead to emotional, cognitive and physiological pathologies.
One of the sleep pattern refers to non-24-hour sleep, people who basically have no sleep problem but whose circadian clock is not entrained. Some blind people are not entrained to the 24-hour day despite a regular life involving work, meals and exercise. To understand why only some and not all blind people suffer from this problem, we must know many other important series of information.
The mammalian clock can only be influenced by light via the retina in the eyes. Those blind people, who have no conscious visual perception may still have a functional Melanopsin System that allows their circadian clock in the SCN to entrain to the 24-hour day. Only those blind people, who have also lost light reception in the Melanopsin system are prone to be un-entrained despite a normal regular life.
Sleep changes with the age
- Increased number and duration of awakenings
- Decreased REM sleep
- Decreased slow wave sleep
- Reduced sleep efficiency
Sleep involves in the fundamental changes in discreet neural network. These neural network plays an essential role in behavior and pathology of mental disorders. Since the sleep and circadian rhythm disruption or disorder [SCRD] is eventually is because of misalignment of internal and actual wakeful sleep clock, Ghrelin & Leptin imbalance ratios are cropped up leading to obesity and typeII diabetes.
Just to make you aware
Ghrelin also known as “hunger hormone” is a hormone produced by enteroendocrine cells of the gastrointestinal tract, it increases food intake. Blood levels of ghrelin are highest before meals when hungry, returning to lower levels after mealtimes.
Leptin is a hormone in the small intestine that helps to regulate energy balance by inhibiting hunger, it gives the feeling of full stomach and signals the brain of restricting any food intake.
How this works?
If we wake up at 7:00AM in the morning and our routine is to have supper by 9:00 PM, now for some reasons our sleep wake cycles are disturbed (examples in today’s precarious situation overtly because of COVID-19) i.e. after dinner we used to sleep by 11 PM, which now (in case) shifted to 2: 00 AM the ghrelin will be triggered and we will like to stuff our intestines and then the Leptin will trigger in the morning not letting us eat or there can be several other cases like this.
Please be informed to the fullest “that because of lack of sleep we might develop the disorders like insomnia, migraine, and Alzheimer’s & many behavioral disorders.” So it is advisable that come what we all may need to get the good quality sleep every night or every day (shift works employees).
Sleep is one of the best treatments / medicine we can gift it our body and help in many aspects to stay healthy, wise & free from all the disorders which might occur because of the sleep deprivation.
Girish Bhardwaj
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